Vioxx And Heart Disease

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Lawyers Try to Tie Vioxx and Heart Disease

Almost every prescription drug on the market has side effects, some more severe than others. Physicians weigh the risks of possible side effects to the benefits of the treatment when determining a patient' s need for the drug. When the manufacturer learned of the high incident risk between Vioxx and heart disease it was pulled from the market.

Non-steroidal anti-inflammatory drugs, used for pain, have been available over the counter for may years, sold under a variety of names such as ibuprofen and naproxen. They all come with the warning that they can cause stomach ulcers and other problems. This is because of the cyclooxygenase (COX) inhibitors, which are part of the products, inhibit what is referred to COX-1, which produces an enzyme responsible for the protection of the stomach lining.

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Researchers found a way to block COX-2 production and not COX-1, which showed promise of a pain reliever that did not have the same side effects of causing stomach problems. The COX-2 enzyme, however, also blocks the production of prostaglandin, and anti-clotting agent. When the effects of Vioxx and heart disease began to surface additional warnings were added to the drug' s label.

The manufacturer told the approving agency, the FDA, this tie-in of Vioxx, and heart disease was only prevalent in patients with a high risk of coronary events, and under a physician' s guidance was safe for use by those without a severe risk, lessening the threat associated with Vioxx and heart disease.

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Drug Pulled From Market

When further studies indicated an increase of heart attacks in patients taking Vioxx and heart disease histories increased four times. An editorial in the New England Journal of Medicine claimed the makers of Vioxx were aware of increased threat of those taking Vioxx and heart disease. Those claims were the primary cause of the additional warnings placed on labels.

However, because of the increased incidents of those taking Vioxx and heart disease events such as heart attack and stroke, Vioxx was pulled from the market in 2005, after six years on the market.

The increased scrutiny tying Vioxx and heart disease has also been the leading factor in drawing the manufacturer into numerous lawsuits around the country. The families of people with histories of significant coronary events, who were taking Vioxx and died, have launched the legal action claiming the tie-in of Vioxx and heart disease is responsible for their loved-ones deaths.

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